The Thermo Scientific™ Pharma mini HME is a GMP compliant conical micro compounder for Hot Melt Extrusion in research and development in the pharmaceutical industry. When developing new drugs, shortening time-to-market and reducing waste of expensive API's and overall development costs provide a distinct competitive advantage. Hence, quick and early assessment of new API/excipient formulations is critical. Hot melt extrusion and continuous processing can lead to speedier formulation development and cost efficient production. The Thermo Scientific Pharma mini HME allows users to identify the right drug candidates for hot melt extrusion by compounding as little as three grams of material.
With the Pharma mini HME, we offer a micro twin-screw compounder which requires as little as three grams of total material to identify the right drug candidates for hot melt extrusion. The compounder with conical co- or counter-rotating screws is designed to minimize waste and reduce downtime necessary for cleaning.
- Requires only 3g (4mL) of material for compounding
- Small footprint, fanless design with separate, touch-screen control for operation in fume cabinet or glovebox applications
- Removable and exchangeable product contact parts for quick and easy cleaning
- IP 54 for protection against dust and water allows the Pharma mini HME to be spray-washed
- Useable as small-scale production unit for throughputs of 100g/h
- Touch screen control with user levels and password protection
- Data logging software as option to record temperatures, torque, and screw speed
- Optional batch conversion kit to use the Pharma mini HME as small batch mixer
- Complementary workflow solution when coupled with the Thermo Scientific™ HAAKE™ MiniJet injection molder
Recommended for:
Materials:
- Pharmaceutical ingredients (API's)
- Excipients
- Medical polymers
- Drug delivery systems
- Soft gels
Applications:
- Hot melt extrusion
- Medical devices
- Implants
- Controlled drug release
- Handling and processing of highly potent API's in a glovebox
A small footprint reduces clean room volumes, and lower ingredient consumption reduces handling and operator exposure.
Compounding and extrusion instrument selection guide
| | Barrel diameter (mm) | Barrel
length
L/D | Da/Di | Achievable output (kg/h)* | Temp. (°C) | Screw design | Max. screw speed (rpm) | Temp. zones ** | Drive power (kW) |
| HAAKE MiniCTW | Conical | | | 0.01–0.1 | 300 | Conical co- and counter rotating | 360 | 2*** | 0.4 |
| Pharma mini HME | Conical | | | 0.01–0.1 | 280 | Conical co- and counter rotating | 360 | 2*** | 0.4 |
| MiniLab 3 | Conical | | | 0.01–0.1 | 350 (420) | Conical co- and counter rotating | 360 | 2*** | 0.4 |
| Laboratory scale |
| Pharma 11 | 11 | 40 | 1.72 | 0.02–2.5 | 280 | Parallel co-rotating | 1000 | 8 | 1.5 |
| Process 11 | 11 | 40 | 1.72 | 0.02–2.5 | 350 (450) | Parallel co-rotating | 1000 | 8 | 1.5 |
| Process 16 | 16 | 40 | 1.73 | 0.4–20 | 350 (450) | Parallel co-rotating | 1000 | 8 | 3.7 |
| Rheomex PTW 16 OS | 16 | 25 (40) | 1.73 | 0.2–10 | 400 (450) | Parallel co-rotating | 1100 | 7 (10) | 7 (16)**** |
| Rheomex PTW 24 OS | 24 | 28 (40) | 1.77 | 0.5–50 | 400 (450) | Parallel co-rotating | 1100 (560) | 7 (10) | 16 (7)**** |
| Rheomex CTW 100 OS | Conical | | | 0.2–5 | 450 | Conical counter rotating | 250 | 3 | 7 (16)**** |
| Pilot processing and production |
| TSE 24 MC | 24 | 28 (40) | 1.77 | 0.5–50 | 400 (450) | Parallel co-rotating | 500 (1000) | 7 (10) | 5.5(11) |
| Pharma 16 | 16 | 40 | 1.73 | 0.2–5 | 300 | Parallel co-rotating | 1000 | 8 | 2.5 |
| Pharma 24 | 24 | 40 | 1.77 | 0.5–20 | 300 | Parallel co-rotating | 1000 | 8 | 11 |
L/D = Ratio of flighted screw length to outer diameter
PC = External computer control
TS = Integrated touchscreen control
* = Material dependent
** = Barrel length dependent
*** = Common set point
****= Driven by PolyLab drive unit
( ) = Optional
For Research Use Only. Not for use in diagnostic procedures.
The Thermo Scientific™ Pharma mini HME is a GMP compliant conical micro compounder for Hot Melt Extrusion in research and development in the pharmaceutical industry. When developing new drugs, shortening time-to-market and reducing waste of expensive API's and overall development costs provide a distinct competitive advantage. Hence, quick and early assessment of new API/excipient formulations is critical. Hot melt extrusion and continuous processing can lead to speedier formulation development and cost efficient production. The Thermo Scientific Pharma mini HME allows users to identify the right drug candidates for hot melt extrusion by compounding as little as three grams of material.
With the Pharma mini HME, we offer a micro twin-screw compounder which requires as little as three grams of total material to identify the right drug candidates for hot melt extrusion. The compounder with conical co- or counter-rotating screws is designed to minimize waste and reduce downtime necessary for cleaning.
Recommended for:
Materials:
Applications:
A small footprint reduces clean room volumes, and lower ingredient consumption reduces handling and operator exposure.
Compounding and extrusion instrument selection guide
length
L/D
Achievable output
(kg/h)*
L/D = Ratio of flighted screw length to outer diameter
PC = External computer control
TS = Integrated touchscreen control
* = Material dependent
** = Barrel length dependent
*** = Common set point
****= Driven by PolyLab drive unit
( ) = Optional
For Research Use Only. Not for use in diagnostic procedures.