Perform material- and labor-effective extrusion and granulation processes with Thermo Scientific™ Pharma 11 Twin-screw Extruder.
With throughput levels from as low as 20g/hour up to 2.5 hg/hour the instrument is suitable for R&D work and small-scale commercial production as well. For the latter, its industry standard PLC makes it easy-to-integrate into existing process control systems. 21 CFR part 11 compliance support and batch report / audit trail options are available.
If you need an easy to convert 2-in-1 machine for hot melt extrusion (HME) to twin-screw granulation (TSG) and wet extrusion, the Pharma 11 Twin-screw Extruder is for you. With its a wide range of available accessories and its full scalability with the range of Thermo Scientific stand-alone pharmaceutical compounding systems.
The Pharma 11 Twin-screw Extruder Features:
- Uses smaller material quantities for faster, cost-effective development
- Converts easily from hot melt extrusion (HME) to twin screw granulation (TSG) applications
- Operates at throughput ranges from 20g/h up to 2.5kg/h
- Processing length: L/D ratio 40:1
- Screw elements and barrel design scale geometrically across the all Thermo Scientific Pharma Extruders and allow easy process scale-up
- Easy-to-operate with user-friendly, intuitive touch screen with integrated feeder control
- Maximize lab space with small footprint machine
- Perfect for glove box or isolator applications with removable touch screen
- All material contact parts are easily removable
- Documentation of extrusion parameters, recipe and batch report, audit trail and suitable for PAT (process analytical technologies)
- GMP and CFR 21 part 11 compliant, full validation available: FAT, SAT, IQ/OQ
Compounding and extrusion instrument selection guide
| | Barrel diameter (mm) | Barrel
length
L/D | Da/Di | Achievable output (kg/h)* | Temp. (°C) | Screw design | Max. screw speed (rpm) | Temp. zones ** | Drive power (kW) |
| HAAKE MiniCTW | Conical | | | 0.01–0.1 | 300 | Conical co- and counter rotating | 360 | 2*** | 0.4 |
| Pharma mini HME | Conical | | | 0.01–0.1 | 280 | Conical co- and counter rotating | 360 | 2*** | 0.4 |
| MiniLab 3 | Conical | | | 0.01–0.1 | 350 (420) | Conical co- and counter rotating | 360 | 2*** | 0.4 |
| Laboratory scale |
| Pharma 11 | 11 | 40 | 1.72 | 0.02–2.5 | 280 | Parallel co-rotating | 1000 | 8 | 1.5 |
| Process 11 | 11 | 40 | 1.72 | 0.02–2.5 | 350 (450) | Parallel co-rotating | 1000 | 8 | 1.5 |
| Process 16 | 16 | 40 | 1.73 | 0.4–20 | 350 (450) | Parallel co-rotating | 1000 | 8 | 3.7 |
| Rheomex PTW 16 OS | 16 | 25 (40) | 1.73 | 0.2–10 | 400 (450) | Parallel co-rotating | 1100 | 7 (10) | 7 (16)**** |
| Rheomex PTW 24 OS | 24 | 28 (40) | 1.77 | 0.5–50 | 400 (450) | Parallel co-rotating | 1100 (560) | 7 (10) | 16 (7)**** |
| Rheomex CTW 100 OS | Conical | | | 0.2–5 | 450 | Conical counter rotating | 250 | 3 | 7 (16)**** |
| Pilot processing and production |
| TSE 24 MC | 24 | 28 (40) | 1.77 | 0.5–50 | 400 (450) | Parallel co-rotating | 500 (1000) | 7 (10) | 5.5(11) |
| Pharma 16 | 16 | 40 | 1.73 | 0.2–5 | 300 | Parallel co-rotating | 1000 | 8 | 2.5 |
| Pharma 24 | 24 | 40 | 1.77 | 0.5–20 | 300 | Parallel co-rotating | 1000 | 8 | 11 |
L/D = Ratio of flighted screw length to outer diameter
PC = External computer control
TS = Integrated touchscreen control
* = Material dependent
** = Barrel length dependent
*** = Common set point
****= Driven by PolyLab drive unit
( ) = Optional
For Research Use Only. Not for use in diagnostic procedures.
Perform material- and labor-effective extrusion and granulation processes with Thermo Scientific™ Pharma 11 Twin-screw Extruder.
With throughput levels from as low as 20g/hour up to 2.5 hg/hour the instrument is suitable for R&D work and small-scale commercial production as well. For the latter, its industry standard PLC makes it easy-to-integrate into existing process control systems. 21 CFR part 11 compliance support and batch report / audit trail options are available.
If you need an easy to convert 2-in-1 machine for hot melt extrusion (HME) to twin-screw granulation (TSG) and wet extrusion, the Pharma 11 Twin-screw Extruder is for you. With its a wide range of available accessories and its full scalability with the range of Thermo Scientific stand-alone pharmaceutical compounding systems.
The Pharma 11 Twin-screw Extruder Features:
Compounding and extrusion instrument selection guide
length
L/D
Achievable output
(kg/h)*
L/D = Ratio of flighted screw length to outer diameter
PC = External computer control
TS = Integrated touchscreen control
* = Material dependent
** = Barrel length dependent
*** = Common set point
****= Driven by PolyLab drive unit
( ) = Optional
For Research Use Only. Not for use in diagnostic procedures.