The Thermo Scientific™ Pharma 24 Twin-Screw Granulator (TSG) is a dedicated system for wet and dry granulation processes. It can be used as a stand-alone instrument or integrated into a modular, continuous manufacturing line that spans from raw materials to final tableting. Such flexibility minimizes scale-up risks.
The Pharma 24 TSG provides consistent and controllable processing, on-demand production, and reduced clean room space and ATEX risk. It is also suitable for process analytical technology (PAT).
The Pharma 24 dedicated TSG provides maximum process flexibility through many features:
- Horizontally split extruder barrel for easy access and cleaning
- Easy-to-operate clamp shell design
- Removable top and bottom liners, made from pharma grade steel
- Main port with availability for 5 additional multi-purpose, top feed/injection ports
- Flexible base for stand-alone operation or easy adaption to existing downstream equipment at an existing production site
Optimal design for challenging environments
The Pharma 24 TSG can set up with an optional design to operate in challenging environments. The liquid temperature control of the TSG barrel ranges from 20°C to 80°C without any electrical heating. The instrument can be set up with 1-3 cooling zones when intensive cooling of the barrel is necessary.
Maximum control and connectivity
For the best possible process control, sensors such as temperature sensors or optional process analytical technology (PAT) sensors can be used with the Pharma 24 TSG. The Pharma 24 TSG is operated from a touch panel on a movable frame, and TCP/IP can be used to integrate it into an existing overarching IT architecture. Maximum user control is delivered via five different user levels with password protection and comprehensive reporting.
Compounding and extrusion instrument selection guide
| | Barrel diameter (mm) | Barrel
length
L/D | Da/Di | Achievable output (kg/h)* | Temp. (°C) | Screw design | Max. screw speed (rpm) | Temp. zones ** | Drive power (kW) |
| HAAKE MiniCTW | Conical | | | 0.01–0.1 | 300 | Conical co- and counter rotating | 360 | 2*** | 0.4 |
| Pharma mini HME | Conical | | | 0.01–0.1 | 280 | Conical co- and counter rotating | 360 | 2*** | 0.4 |
| MiniLab 3 | Conical | | | 0.01–0.1 | 350 (420) | Conical co- and counter rotating | 360 | 2*** | 0.4 |
| Laboratory scale |
| Pharma 11 | 11 | 40 | 1.72 | 0.02–2.5 | 280 | Parallel co-rotating | 1000 | 8 | 1.5 |
| Process 11 | 11 | 40 | 1.72 | 0.02–2.5 | 350 (450) | Parallel co-rotating | 1000 | 8 | 1.5 |
| Process 16 | 16 | 40 | 1.73 | 0.4–20 | 350 (450) | Parallel co-rotating | 1000 | 8 | 3.7 |
| Rheomex PTW 16 OS | 16 | 25 (40) | 1.73 | 0.2–10 | 400 (450) | Parallel co-rotating | 1100 | 7 (10) | 7 (16)**** |
| Rheomex PTW 24 OS | 24 | 28 (40) | 1.77 | 0.5–50 | 400 (450) | Parallel co-rotating | 1100 (560) | 7 (10) | 16 (7)**** |
| Rheomex CTW 100 OS | Conical | | | 0.2–5 | 450 | Conical counter rotating | 250 | 3 | 7 (16)**** |
| Pilot processing and production |
| TSE 24 MC | 24 | 28 (40) | 1.77 | 0.5–50 | 400 (450) | Parallel co-rotating | 500 (1000) | 7 (10) | 5.5(11) |
| Pharma 16 | 16 | 40 | 1.73 | 0.2–5 | 300 | Parallel co-rotating | 1000 | 8 | 2.5 |
| Pharma 24 | 24 | 40 | 1.77 | 0.5–20 | 300 | Parallel co-rotating | 1000 | 8 | 11 |
L/D = Ratio of flighted screw length to outer diameter
PC = External computer control
TS = Integrated touchscreen control
* = Material dependent
** = Barrel length dependent
*** = Common set point
****= Driven by PolyLab drive unit
( ) = Optional
For Research Use Only. Not for use in diagnostic procedures.
The Thermo Scientific™ Pharma 24 Twin-Screw Granulator (TSG) is a dedicated system for wet and dry granulation processes. It can be used as a stand-alone instrument or integrated into a modular, continuous manufacturing line that spans from raw materials to final tableting. Such flexibility minimizes scale-up risks.
The Pharma 24 TSG provides consistent and controllable processing, on-demand production, and reduced clean room space and ATEX risk. It is also suitable for process analytical technology (PAT).
The Pharma 24 dedicated TSG provides maximum process flexibility through many features:
Optimal design for challenging environments
The Pharma 24 TSG can set up with an optional design to operate in challenging environments. The liquid temperature control of the TSG barrel ranges from 20°C to 80°C without any electrical heating. The instrument can be set up with 1-3 cooling zones when intensive cooling of the barrel is necessary.
Maximum control and connectivity
For the best possible process control, sensors such as temperature sensors or optional process analytical technology (PAT) sensors can be used with the Pharma 24 TSG. The Pharma 24 TSG is operated from a touch panel on a movable frame, and TCP/IP can be used to integrate it into an existing overarching IT architecture. Maximum user control is delivered via five different user levels with password protection and comprehensive reporting.
Compounding and extrusion instrument selection guide
length
L/D
Achievable output
(kg/h)*
L/D = Ratio of flighted screw length to outer diameter
PC = External computer control
TS = Integrated touchscreen control
* = Material dependent
** = Barrel length dependent
*** = Common set point
****= Driven by PolyLab drive unit
( ) = Optional
For Research Use Only. Not for use in diagnostic procedures.